Author： Tang Oi Shan Ong Charas Y.T. Tse Ka Yu Ng Ernest H.Y. Lee Sharon W.H. Ho Pak Chung
Publisher： Oxford University Press
ISSN： 1460-2350
Source： Human Reproduction, Vol.21, Iss.1, 2006-01, pp. : 189-192
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Abstract
BACKGROUND: This randomized controlled trial compared the use of sublingual misoprostol with or without an additional 1 week course of sublingual misoprostol for the medical management of silent miscarriage. METHODS: A total of 180 women who had silent miscarriage (<13 weeks)="" was="" given="" 600="" µg="" of="" misoprostol="" every="" 3="" h="" for="" a="" maximum="" of="" three="" doses.="" these="" women="" were="" randomized="" into="" two="" groups:="" (i)="" no="" extended="" course="" of="" misoprostol="" or="" (ii)="" an="" extended="" course="" of="" sublingual="" misoprostol="" 400="" µg="" daily="" for="" 1="" week.="" the="" primary="" outcome="" measure="" was="" complete="" miscarriage="" rate.="" results:="" the="" success="" rates="" for="" complete="" miscarriage="" were="" similar="" in="" both="" groups="" (group="" 1:="" 92.2%;="" 95%="" ci:="" 86.1–97.5%="" and="" group="" 2:="" 93.2%;="" 95%="" ci:="" 84.6–96.8%).="" there="" were="" no="" serious="" complications.="" the="" incidence="" of="" diarrhoea="" was="" higher="">P < 0.01)="" in="" the="" group="" with="" an="" extended="" course="" of="" sublingual="" misoprostol.="" other="" side-effects="" were="" similar.="" conclusion:="" sublingual="" misoprostol="" is="" useful="" for="" the="" management="" of="" silent="" miscarriage.="" an="" additional="" 1="" week="" course="" of="" sublingual="" misoprostol="" did="" not="" improve="" the="" success="" rate="" or="" shorten="" the="" duration="" of="" vaginal="" bleeding.="" instead,="" it="" increased="" the="" incidence="" of="" diarrhoea.="">
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