Author: Beck Olof
Publisher: Oxford University Press
ISSN: 0146-4760
Source: Journal of Analytical Toxicology, Vol.35, Iss.5, 2011-06, pp. : 257-263
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Abstract
This study aimed at develop and validate the procedure for collecting exhaled breath for drug testing. Patients receiving methadone maintenance treatment were recruited for the study. Methadone levels were measured using liquid chromatography– electrospray-tandem mass spectrometry. The sampling device was based on a 47-mm C18 filter and used under pressure to aid flow through the filter. The mouth was rinsed before sampling, and the device was constructed to protect against any saliva contamination. Methadone was present in breath samples before and after the daily intake of methadone. The mean (± SD) pre-dose level was found to be 135 ± 109 pg/min (