Author: Wu J. Davis M.D. Owens R.A.
Publisher: Elsevier
ISSN: 0003-9861
Source: Archives of Biochemistry and Biophysics, Vol.389, Iss.2, 2001-05, pp. : 271-277
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Abstract
The strand-specific, site-specific endonuclease (nicking) activity of the Rep68 and Rep78 (Rep68/78) proteins of adeno-associated virus type 2 (AAV) is involved in AAV replication, and appears to be involved in AAV site-specific integration. Rep68/78 cuts within the inverted terminal repeats (ITRs) of the AAV genome and in the AAV preferred integration locus on human chromosome 19 (
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