Novel nanocrystals as a platinum-delivery vehicle for chemotherapy

Author： Smith Danielle K Rasch Michael R Korgel Brian A

ISSN： 1743-5889

Source： Nanomedicine, Vol.2, Iss.6, 2007-12, pp. : 943-949

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Abstract

Evaluation of: Gao J, Liang G, Zhang B et al.: FePt@CoS₂Yolk-shell nanocrystals as a potent agent to kill HeLa cells. J. Am. Chem. Soc. 129(5), 1428––1433 (2007) [1]. Here, a recent paper describing the synthesis and cytotoxicity of Pt-containing yolk-shell nanocrystals is evaluated. The authors synthesized FePt nanocrystals and encapsulated them in CoS₂ shells. Cervical cancer cells (HeLa) were then exposed to these nanoparticles and examined for cell viability. The nanocrystals exhibited cytotoxicity at Pt concentrations lower than that of the well-established organoplatinum chemotherapy drug, cisplatin. The nanocrystal synthesis, the potential of these nanocrystals for chemotherapy and the implications of this study on the future development of a new class of ‘‘nanochemotherapeutics’’ are discussed.