Author： NARIO KAZUHIKO KITANO IKUO MORI NOZOMU MATSUNAGA TAKASHI
Publisher： Informa Healthcare
ISSN： 0001-6489
Source： Acta Oto-Laryngologica, Vol.118, Iss.2, 1998-07, pp. : 198-205
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Abstract
The effect of endoplasmic Ca2+-ATPase inhibitors on cochlear potentials was examined in the guinea-pig. Perilymphatic perfusion with thapsigargin (10-6M) produced a significant decrease in the amplitudes of cochlear microphonics, negative summating potential and compound action potential, and a significant prolongation of N1 latency with no change in the endocochlear potential. These changes were all dose dependent. Another endoplasmic Ca2+-ATPase inhibitor, cyclopiazonic acid (10-5M), produced the same effects as thapsigargin on cochlear potentials. These results suggest that endoplasmic Ca2+-ATPase inhibitors may have inhibitory functions on cochlear potentials.
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