Author： Kanoh Naoyuki
Publisher： Informa Healthcare
ISSN： 0001-6489
Source： Acta Oto-Laryngologica, Vol.118, Iss.6, 1998-12, pp. : 817-820
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Abstract
On the basolateral infoldings of the strial marginal cells in the cochlea, Na-K ATPase activity is abundant. To clarify the humoral control by norepinephrine, K-NPPase activity of strial marginal cells in the cochlea was investigated in normal, reserpine, norepinephrine (NE), reserpine plus NE-treated guinea pigs using a cerium-based method. K-NPPase activity was almost completely decreased 3-20 days after reserpine administration. At 10 days after reserpinization and following NE repeated treatment, enzyme activity was detectable. These results suggested that norepinephrine might restore and regulate strial K-NPPase activity.
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