Effects of selective cochlear toxicity and vestibular deafferentation on vestibular evoked myogenic potentials in guinea pigs

Author： Shojaku Hideo Zang Rui Li Tsubota Masahito Fujisaka Michiro Hori Etsuro Nishijo Hisao Watanabe Yukio

Publisher： Informa Healthcare

ISSN： 0001-6489

Source： Acta Oto-Laryngologica, Vol.127, Iss.4, 2007-01, pp. : 430-435

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Abstract

Conclusion: The findings suggest that sound-evoked myogenic potentials on the guinea pig sternocleidomastoid muscle (SM) originate from the vestibular end organ and not from the cochlea of the inner ear. Objective: Studies in animals of the sound evoked vestibular myogenic potentials on the SM should aid in elucidating the pathway of the vestibular-evoked myogenic potential (VEMP). However, details of the pathway of the VEMP remain to be elucidated. This study aimed to clarify aspects of this pathway. Materials and methods: In the present study, short latency biphasic myogenic potentials on the SM in guinea pigs were induced by an intense brief sound. Results: The thresholds of the potentials were 67 dB SPL above those of the auditory brainstem response (ABR). The potentials were eliminated by a vestibular deafferentation, but were observed after selective cochlea toxicity using an amikacin injection.