Partial laryngopharyngectomy in the treatment of squamous cell carcinoma of hypopharynx: Analysis of the oncologic results and laryngeal preservation rate

Author： Kuo Yen-ling Chang Chia-Fan Chang Shyne-Yih Chu Pen-Yuan

Publisher： Informa Healthcare

ISSN： 0001-6489

Source： Acta Oto-Laryngologica, Vol.132, Iss.12, 2012-12, pp. : 1342-1346

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Abstract

AbstractConclusion: Partial laryngopharyngectomy (PLP) provides acceptable oncologic results and laryngeal preservation rate in selected patients with squamous cell carcinoma of the hypopharynx. Even when local recurrence develops, the chance of successful salvage is still high. Objectives: To evaluate the oncologic results and laryngeal preservation rate in patients with squamous cell carcinoma of the hypopharynx who underwent PLP. Methods: The results of 39 patients who underwent PLP were compared with those of 91 patients who underwent total laryngectomy (TL). Results: The distribution of the primary T stages were 23 (59%) pT2, 9 (23%) pT3, and 7 (18%) pT4; the pathologic stages were 8 patients (21%) stage II, 9 (23%) stage III, and 22 (56%) stage IV. All of the patients also had ipsilateral or bilateral neck dissections. Eighteen patients (46%) received postoperative adjuvant therapy. After a median follow-up of 39 months, 17 patients (44%) had recurrence, including 12 local, 2 regional, and 3 distant lesions. The 5-year overall and disease-specific survival were 44% and 56%, respectively; functional preservation was 62%. The recurrence rate was similar in patients treated with PLP and TL (44% vs 36%, p = 0.431); the local recurrence rate was higher after PLP than after TL (31% vs 8%, p = 0.001). The salvage surgery was successful in four of the six patients (67%). After salvage treatment, the 5-year overall survival (44% vs 47%) and disease-specific survival (56% vs 62%) were similar in the two groups.