Dietary supplementation of carbonate promotes spontaneous tumorigenesis in a rat gastric stump model

Author： Ehrnström Roy A Veress Béla Arvidsson Stefan Sternby Nils H Andersson Tommy Lindström Clas G

ISSN： 0036-5521

Source： Scandinavian Journal of Gastroenterology, Vol.41, Iss.1, 2006-01, pp. : 12-20

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Objective . Food supplements are known to affect the development of gastric adenocarcinoma. In this study, an animal model of gastric resection was used to investigate the effects of calcium carbonate on spontaneous development of gastric adenocarcinoma. Material and methods . Ninety-two Wistar rats with gastric resections (performed to induce spontaneous gastric cancer) and 60 without resections (controls) were used to analyse the carcinogenic potential of different ion supplements in food. Results . Among the resected rats, cancer developed in 3 out of 18 (17%, NS) given NaCl but in 11 out of 18 (61%, p 4 , which was lower than the rate observed in the resected control group fed a normal diet, although this difference was not statistically significant. However, tumour development increased significantly in the resected animals given a diet supplemented with NaHCO 3 (tumours in 13 out of 24 rats, 54%; p