Colonic mucosal lesions associated with low-dose aspirin: A case control study

Author： Shibuya Tomoyoshi Ohkusa Toshifumi Yokoyama Tetsuji Matsumoto Kenshi Beppu Kazuko Sakamoto Naoto Osada Taro Nagahara Akihito Otaka Michiro Ogihara Tatsuo Watanabe Sumio

Publisher： Informa Healthcare

ISSN： 0036-5521

Source： Scandinavian Journal of Gastroenterology, Vol.46, Iss.7-8, 2011-07, pp. : 810-817

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Abstract

Abstract Objective. Low-dose aspirin (LDA) is widely used because it reduces the risk of vascular events in patients with atherosclerosis. Recently, there has been a substantial increase in prescriptions for LDA. We analyzed the risk of colonic mucosal lesions associated with the long-term use of LDA. Material and methods. Among Japanese patients who underwent a colonoscopy between January 2004 and December 2006, 199 colitis cases and 5764 non-colitis controls were identified after excluding 749 patients based on study criteria. The history of LDA use was compared between the cases and controls and the multivariate (age-, sex- and underlying diseases-) adjusted odds ratio (OR) was estimated using a multiple logistic regression model. Results. The adjusted OR for colonic mucosal lesions associated with LDA use versus non-use was 1.45 [95% confidence interval (CI), 0.87––2.42; p == 0.152]. In terms of gender differences, the OR for LDA-induced colitis in females was significantly increased at 2.55 (95% CI, 1.31––4.94; p == 0.006) but was not significantly increased in males at 0.70 (95% CI, 0.34––1.45; p == 0.334). Conclusions. In females, LDA increased the risk of colonic mucosal lesions, suggesting that LDA may contribute to the pathogenesis of colonic ulceration or colitis. Therefore, it is essential that prescribing physicians be aware of the risk of LDA-induced colonic lesions.