Oral oxycodone hydrochloride versus epidural anaesthesia for pain control after radical retropubic prostatectomy

Author： Hohwü Lena Akre Olof Bergenwald Lennart Törnblom Magnus Gustafsson Ove

ISSN： 0036-5599

Source： Scandinavian Journal of Urology and Nephrology, Vol.40, Iss.3, 2006-05, pp. : 192-197

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

To evaluate whether combined oral intake of paracetamol (4×1 g) + oxycodone hydrochloride (2×10 mg) is adequate and equivalent to epidural anaesthesia (EDA) with respect to postoperative pain control and postoperative mobilization after radical retropubic prostatectomy (RRP). Forty consecutive patients scheduled for RRP were randomized to either: EDA with ropivacaine + paracetamol (4×1 g tablet) + injected or oral morphine on demand (EDA group); or infiltration of 25–40 ml of 0.25% bupivacaine into the wound + oxycodone hydrochloride (2×10 mg tablet) + paracetamol (4×1 g tablet) + injected or oral morphine on demand (OXY group). The groups were compared with respect to pain control determined by means of a visual analogue scale (VAS), time to free mobilization, hospital stay, complications, operation time and bleeding. Both analgesic regimens provided satisfactory analgesia, i.e. VAS scores remained significantly below 4 ( p