Author： Liu Haihong Li Lin Hao Yihui Cao Dong Xu Lin Rohrbaugh Robert Xue Zhimin Hao Wei Shan Baoci Liu Zhening
Publisher： Informa Healthcare
ISSN： 0095-2990
Source： The American Journal of Drug and Alcohol Abuse, Vol.34, Iss.5, 2008-09, pp. : 562-575
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Objectives: Fractional anisotropy (FA) via diffusion tensor imaging (DTI) can quantify the white matter integrity. Exposure to addictive drugs, such as alcohol, cocaine, methamphetamine, marijuana, and nicotine has been shown to alter FA. White matter abnormalities have been shown, but it remains unclear whether the white matter FA is altered in heroin dependence. Methods: Utilizing DTI, we investigated the FA difference between heroin-dependent and control subjects by a voxel-based strategy. The FA values of the identified regions were calculated from the FA image of each subject and were correlated with clinical features including months of heroin use, age, education, and dose of methadone. Results: Reduced FA among 16 heroin dependent subjects was located in the bilateral frontal sub-gyral regionsm, right precentral and left cingulate gyrus. FA in the right frontal sub-gyral was negatively correlated with duration of heroin use. Conclusion: The disrupted white matter integrity in right frontal white matter may occur in continuous heroin abuse.
Related content
Access to resources
Recommend
