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The Relationship between Antidepressant Use and Smoking Cessation in Pregnant Women in Treatment for Substance Abuse

Author： Chisolm Margaret S. Brigham Emily P. Tuten Michelle Strain Eric C. Jones Hendrée E.

Publisher： Informa Healthcare

ISSN： 0095-2990

Source： The American Journal of Drug and Alcohol Abuse, Vol.36, Iss.1, 2010-01, pp. : 46-51

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

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Abstract

Background: Bupropion's efficacy for smoking cessation in pregnant women is unknown. Objectives: To determine if substance-dependent women prescribed bupropion smoked fewer cigarettes/day than those prescribed citalopram/escitalopram or no antidepressant medication. Methods: Comparison of smoking in bupropion (n = 11), citalopram/escitalopram (n = 17), and no antidepressant (n = 28) groups. Results and Conclusions: Trend for greater decrease in smoking for the bupropion vs. citalopram/escitalopram group [−6.4 vs. −.4 cigarettes/day (p = .276)], although the bupropion decrease was similar to that seen in the no antidepressant group [−5.3 cigarettes/day]. Scientific Significance: Data support continued study of bupropion in depressed pregnant substance-dependent smokers.

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