Author： Morris Alison Noakes Manny Clifton Peter
Publisher： Informa Healthcare
ISSN： 0277-0903
Source： Journal of Asthma, Vol.38, Iss.4, 2001-06, pp. : 311-319
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Abstract
We investigated in a clinical setting whether increased intake of linoleic acid alters respiratory function in 26 mild asthmatics. Subjects completed a 16-week-dietary intervention comprising 8 weeks eating an enriched n-6 polyunsaturated fat diet (9.2% energy from linoleic acid) and consuming either a high monounsaturated or saturated fat diet in a random cross-over resign for 8 weeks. Neither FEV 1 nor PC 20 values changed significantly after increased linoleic acid consumption when compared with the other diets. Increased consumption of linoleic acid caused a 20% rise (p ≤ 0.01) in plasma linoleic acid, a 38% decrease (p ≤ 0.01) in plasma eicosapentaenoic acid, but no change in arachidonic acid. There were no changes in symptom scores or bronchodilator use.
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