Author： Blacquiere Johanna M Sicora Oana Vogels Christopher M Čuperlović-Culf Miroslava Decken Andreas Ouellette Rodney J Westcott Stephen A
Publisher： NRC Research Press
ISSN： 1480-3291
Source： Canadian Journal of Chemistry, Vol.83, Iss.12, 2005-12, pp. : 2052-2059
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Abstract
The addition of formylphenylboronic acid derivatives to urea and ethyl acetoacetate proceeds in the absence of an additional Lewis acid catalyst to give the corresponding dihydropyrimidinones (Biginelli products) in good yields. Novel boron-containing dihydropyrimidinones have been investigated for their ability to act as anticancer agents against the breast cancer cell line MCF7.
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