Chemically Induced Drosophila melanogaster Mutants with Changes in Brain Structure

Author： Shcherbata G. R.   Matiytsiv N. P.   Chernik Ya. I.   Maksimiv D. V.  

Publisher： MAIK Nauka/Interperiodica

ISSN： 1022-7954

Source： Russian Journal of Genetics, Vol.40, Iss.9, 2004-09, pp. : 1051-1055

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Abstract

Neurodegenerative human diseases are caused by nerve cell death and anatomical changes in some brain regions. Molecular genetic studies of Drosophila showed that this organism can serve as a valuable test-system for conserved mechanisms underlying human nervous system disorders. Analysis of brain functions is possible when the mutants with disturbed functions are available. In this study, we have developed a unique collection of Drosophila melanogaster mutants with morphological and neurodegenerative changes in brain structure, which were induced by chemical mutagens.

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