Study of genotoxicity and antigenotoxicity of the Cotinus coggygria Scop. methanol extract by Drosophila melanogaster sex-linked recessive lethal test

Author： Stanić S.   Matić S.   Đelić G.   Mihailović M.   Bogojević D.   Solujić S.  

Publisher： MAIK Nauka/Interperiodica

ISSN： 1022-7954

Source： Russian Journal of Genetics, Vol.47, Iss.7, 2011-07, pp. : 770-774

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Abstract

The genotoxic and antigenotoxic effects of Cotinus coggygria Scop. methanol extract was investigated using the Drosophila sex-linked recessive lethal (or SLRL) test. The results presented here show that the methanol extract of Cotinus coggygria in a concentration of 5% and artificial chemical agent ethyl methanesulfonate EMS (0.75 ppm) induce recessive lethal mutations on X-chromosome on Drosophila melanogaster in all broods (I, II and III). Post-treatment with lower concentration of the methanol extract of Cotinus coggygria (2%) was effective in reducing genotoxicity of mutagen.

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