Synthesis of Dimethyl 2-(2-Alkyl-1,3-diaryl-3-oxopropyl)malonates and Their Reactions with Amines

Author： Shchepin V.   Korzun A.   Poroshina N.  

Publisher： MAIK Nauka/Interperiodica

ISSN： 1070-3632

Source： Russian Journal of General Chemistry, Vol.75, Iss.4, 2005-04, pp. : 597-604

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Abstract

Zinc enolates generated from 1-aryl-2-bromoalkanones and zinc react with dimethyl 2-(1-arylmethylene)malonate to form dimethyl 2-(2-alkyl-1,3-diaryl-3-oxopropyl)malonates. The latter react with benzylamine or cyclohexylamine to form the corresponding disubstituted amides, while the reactions with piperidine, morpholine, and p-methoxyaniline provide monosubstituted amides of the corresponding target derivatives.

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