Author： Shchepin V. Fotin D.
Publisher： MAIK Nauka/Interperiodica
ISSN： 1070-4280
Source： Russian Journal of Organic Chemistry, Vol.41, Iss.7, 2005-07, pp. : 1011-1015
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Reformatsky reagent obtained by treatment of methyl α-bromoisobutyrate with zinc reacts with dimethyl 2-arylmethylidenemalonates to give trimethyl 2-aryl-3-methylbutane-1,1,3-tricarboxylates. The reaction of the same compound with ethyl 3-aryl-2-(4-methylphenylcarbamoyl)acrylates yields cyclic products, ethyl 4-aryl-5,5-dimethyl-1-(4-methylphenyl)-2,6-dioxopiperidine-3-carboxylates. Treatment of the latter with morpholine and phenylhydrazine leads to the corresponding 4-aryl-5,5-dimethyl-1-(4-methylphenyl)-2,6-dioxopiperidine-3-carboxylic acid morpholides and phenylhydrazides. The products are formed as a single diastereoisomer.
Related content
By Shchepin V. V. Fotin D. V. Vakhrin M. I.
Russian Journal of Organic Chemistry, Vol. 40, Iss. 6, 2004-06 ,pp. :
Access to resources
Recommend
By Shchepin V. V. Fotin D. V. Shurov S. N.
Russian Journal of Organic Chemistry, Vol. 39, Iss. 9, 2003-09 ,pp. :
By Shchepin V. Kirillov N. Vakhrin M. Bayanova O. Shurov S. Silaichev P.
Russian Journal of General Chemistry, Vol. 76, Iss. 7, 2006-07 ,pp. :