Cloning and Identification of a Novel Human RNPC3 Gene That Encodes a Protein with Two RRM Domains and Is Expressed in the Cell Nucleus

Author： Zhao Enpeng   Li Jinsong   Xie Yi   Jin Wei   Zhang Zhen   Chen Jinzhong   Zeng Li   Yin Gang   Qian Ji   Wu Hai   Ying Kang   Zhao Robert Chunhua   Mao YuMin  

Publisher： Springer Publishing Company

ISSN： 0006-2928

Source： Biochemical Genetics, Vol.41, Iss.9-10, 2003-10, pp. : 315-323

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

The RNA recognition motifs (RRM) domain is one of the most common eukaryotic protein folds. Proteins containing RRM domains function in important steps of posttranscriptional regulation of gene expression and are involved in processing and transport of mRNA precursors. Here we describe the cloning and characterization of a novel human RNPC3 gene containing two RNA recognition motifs. The 1870 bp cDNA encodes a protein with 517 amino acids. It also contains two bipartite nuclear targeting sequences, which is important for nuclear targeting for proteins, especially those functioning in the cell nucleus. The GFP location of the RNPC3 gene product shows that this protein is located in the cell nucleus. RT-PCR reveals that it is abundantly expressed in kidney and pancreas.

Related content

cDNA Cloning, Genomic Organization, and Chromosomal Localization of a Novel Human Gene That Encodes a Kinesin-Related Protein Highly Similar to Mouse Kif3C

By Telford E.A.R.   Wightman P.   Leek J.   Markham A.F.   Lench N.J.   Bonthron D.T.  

Biochemical and Biophysical Research Communications, Vol. 242, Iss. 2, 1998-01 ,pp. : 407-412 (6)

Elsevier

Access to resources Recommend Favorite

A Novel Human Homologue of the SH3BGR Gene Encodes a Small Protein Similar to Glutaredoxin 1 of Escherichia coli

By Mazzocco M.   Arrigo P.   Egeo A.   Maffei M.   Vergano A.   Di Lisi R.   Ghiotto F.   Ciccone E.   Cinti R.   Ravazzolo R.   Scartezzini P.  

Biochemical and Biophysical Research Communications, Vol. 285, Iss. 2, 2001-07 ,pp. : 540-545 (6)

Elsevier

Access to resources Recommend Favorite

Identification and characterization of a novel testis-specific gene CKT2 , which encodes a substrate for protein kinase CK2

By Bai Xiyuan  

Nucleic Acids Research, Vol. 37, Iss. 8, 2009-05 ,pp. : 2699-2711 (13)

Oxford University Press

Access to resources Recommend Favorite

Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis

By Cao Yi  

DNA Sequence, Vol. 18, Iss. 4, 2007-01 ,pp. : 312-315 (4)

Informa Healthcare

Access to resources Recommend Favorite

Differentially Expressed cDNAs in PLCβ3-Induced Tumor Suppression in a Human Endocrine Pancreatic Tumor Cell Line: Activation of the Human Mismatch Repair Protein 3 Gene

By Stålberg P.   Lopez-Egido J.R.   Wang S.   Gobl A.   Öberg K.   Skogseid B.  

Biochemical and Biophysical Research Communications, Vol. 281, Iss. 1, 2001-02 ,pp. : 227-231 (5)

Elsevier

Access to resources Recommend Favorite