Author： Kvacheva Z.B. Shukanova N.A. Votyakov V.I. Lobanok E.S. Vorobei A.V. Nikolaeva S.N.
Publisher： Springer Publishing Company
ISSN： 0007-4888
Source： Bulletin of Experimental Biology and Medicine, Vol.135, Iss.4, 2003-04, pp. : 384-387
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Abstract
Membranotropic amphiphilic chromophore merocyanine 540 sensitized photodynamic inhibition of drug-resistant and sensitive variants of type I herpes simplex virus in cultured Vero cell. Optimal conditions of photodamage to virus particles and infected cells were determined (merocyanine 540 concentration 1 μM, illumination dose 32.5-65.0 kJ/m2, exposure at early stages of infection). Infected cells actively bind the photosensitizer, which explains their selective photodamage.
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