Megakaryocytopoiesis under Hypoxic Conditions

Author: Lebedeva E. V.   Yushkov B. G.   Chereshnev V. A.  

Publisher: Springer Publishing Company

ISSN: 0007-4888

Source: Bulletin of Experimental Biology and Medicine, Vol.136, Iss.6, 2003-12, pp. : 554-556

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Abstract

Acute and chronic hypoxia led to acceleration of proliferation and differentiation of bone marrow megakaryocytes and increase in their functional activity. The count of young cells in the peripheral blood increased during acute hypoxia. Chronic hypoxia led to increase in the number of old platelets with lower functional activity, which was accompanied by thrombocytosis.