Effect of in vivo hypoxic preconditioning on changes in intracellular calcium content induced by long-term anoxia in rat brain slices

Author: Semenov D.   Miller O.   Samoilov M.  

Publisher: Springer Publishing Company

ISSN: 0007-4888

Source: Bulletin of Experimental Biology and Medicine, Vol.138, Iss.10, 2004-10, pp. : 338-340

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Abstract

We studied changes in intracellular calcium content induced by 10-min anoxia in olfactory cortex slices from rats exposed to single or 3-fold moderate hypobaric hypoxia (“ascend” at 5000 m). Repeated preconditioning with moderate hypobaric hypoxia produced a neuroprotective effect. This treatment abolished pathological calcium overload in brain slices induced in vitro by 10-min test anoxia.

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