Author： Chekhonin V. Lebedev S. Ryabukhin I. Petrov S. Gurina O. Dmitrieva T. Volkov A. Kashparov I. Skoblov Yu.
Publisher： Springer Publishing Company
ISSN： 0007-4888
Source： Bulletin of Experimental Biology and Medicine, Vol.138, Iss.10, 2004-10, pp. : 343-347
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Preparations of I125-labeled monoclonal antibodies against neurospecific enolase and mouse plasma IgG1 were injected intravenously to rats immediately after unilateral occlusion of the middle cerebral artery. Radioactivity of I125-labeled monoclonal antibodies against neurospecific enolase in the brain tissue progressively increased, reached a maximum by the 48th hour, and remained practically unchanged after 72 h. At the same time radioactivity of labeled IgG1 in the brain tissue and radioactivity of both preparations in the blood, liver, spleen, kidneys, heart, and lungs decreased over 72 h. Selective accumulation of I125-labeled monoclonal antibodies against neurospecific enolase was less significant in the brain tissue of the contralateral hemisphere and cerebellum not exposed to ischemia.
Related content
By Chekhonin V. Lebedev S. Ryabukhin I. Petrov S. Gurina O. Dmitrieva T. Volkov A. Kashparov I. Skoblov Yu.
Bulletin of Experimental Biology and Medicine, Vol. 138, Iss. 4, 2004-10 ,pp. :
Access to resources
Recommend
By Vilas Dolores Gomis Meritxell Blanco Miguel Cortés Jordi Millán Mònica Ossa Natalia Pérez de la Dorado Laura López-Cancio Elena Suñol Anna Dávalos Antoni
Chronobiology International, Vol. 29, Iss. 10, 2012-12 ,pp. :
By Zubkov E. Baklaushev V. Kardashova K. Gurina O. Morozova A. Storozheva Z. Kekelidze Z. Chekhonin V.
Bulletin of Experimental Biology and Medicine, Vol. 155, Iss. 4, 2013-08 ,pp. :