Author： Volkov E. Sabirova A. Nurullin L. Zefirov A.
Publisher： Springer Publishing Company
ISSN： 0007-4888
Source： Bulletin of Experimental Biology and Medicine, Vol.142, Iss.6, 2006-12, pp. : 720-722
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Abstract
Potential created by electrogenic ionic pumps under conditions of maximum activation in a warm standard ionic medium with K+ after preincubation in cold potassium-free solution has two components: a higher ouabaine-insensitive “stationary” component, and a lower “regulatory” component sensitive to ouabaine, furosemide, and removal of Cl− or Ca2+ from the medium. Functional heterogeneity of electrogenic ionic pumps is hypothesized implying the existence of two components: “stationary” (not regulated extracellularly) and “regulatory” (controlled and directly related to active Cl− transfer).
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