Author： Avgustinovich D. Vishnivetskaya G. Koryakina L.
Publisher： Springer Publishing Company
ISSN： 0007-4888
Source： Bulletin of Experimental Biology and Medicine, Vol.149, Iss.1, 2010-07, pp. : 57-61
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Abstract
We studied the effect of 5-HT1A receptor agonist buspirone on behavior of male C57Bl/6J mice in the “partition” test, which reflects communicativeness of animals. Single administration of buspirone (1 mg/kg) to intact mice and animals experienced defeats in 20 intermale confrontations impaired their communicativeness, especially in intact animals. On the contrary, administration of buspirone (1 mg/kg) to losers starting from day 5 of intermale confrontations for 2 weeks produced a positive effect and prevented impairment of communicativeness by day 20 of confrontations. The role of brain 5-HT1A receptors in these processes is discussed.
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