Morphofunctional Characteristics of Fetoplacental Barrier of Placental Villi during Pregnancy Complicated by Herpes-Virus Infection

Author: Lutsenko M.   Andrievskaya I.  

Publisher: Springer Publishing Company

ISSN: 0007-4888

Source: Bulletin of Experimental Biology and Medicine, Vol.149, Iss.4, 2010-10, pp. : 537-539

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Abstract

Analysis of placenta homogenate from pregnant women having an episode of herpes-virus infection during the third trimester revealed suppression of Bcl-2 protein activity and increase in caspase 3 concentration. Activity of Bcl-2 protein decreases with increasing the titer of antibodies to herpes virus. Increased caspase-3 activity increases the risk of DNA damage in syncytiotrophoblast nuclei.

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