Synthesis of 7-oxopyrrolo-[3,2-d]pyrimidine 5-oxides by the rearrangement of 6-alkynyl-5-nitropyrimidines

Author： Tumkevicius S.   Susvilo I.   Brukstus A.  

Publisher： Springer Publishing Company

ISSN： 0009-3122

Source： Chemistry of Heterocyclic Compounds, Vol.40, Iss.10, 2004-10, pp. : 1335-1338

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Abstract

A method is proposed for the synthesis of 6-substituted 4-amino-7-oxopyrrolo[2,3-d]pyrimidine 5-oxides which includes a Sonogashira reaction of 4-amino-6-chloro-5-nitropyrimidine with terminal alkynes and subsequent rearrangement of the 6-alkynyl-5-nitropyrimidines obtained.

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