Author： Levina V. Grigor'ev N. V. Granik V. G.
Publisher： Springer Publishing Company
ISSN： 0009-3122
Source： Chemistry of Heterocyclic Compounds, Vol.40, Iss.4, 2004-04, pp. : 507-509
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Abstract
The metabolic chain of the antihypertensive drug Molsydomin, which belongs to the group of sydnonimine derivatives, was modelled in vitro with the psychotropic drugs Sydnophen and Sydnocarb, which are also derivatives of sydnonimine. Like Molsydomin, Sydnophen and Sydnocarb are hydrolyzed to N-nitroso compounds which liberate nitrogen monoxide, NO, on subsequent oxidation which may be related to the pharmacological effects of these drugs.
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