Author: Gupta Ritu Kazmi Imran Afzal Muhammad Khan Ruqaiyah Chauhan Mohit Al-Abbasi Fahad Ahmad Aftab Anwar Firoz
Publisher: Springer Publishing Company
ISSN: 0300-8177
Source: Molecular and Cellular Biochemistry, Vol.384, Iss.1-2, 2013-12, pp. : 279-285
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Abstract
Sulfonamides have been reported to possess substantial antitumor activity as they act as carbonic anhydrase inhibitors. In addition, selenium appears to have a protective effect at various stages of cancer due to its antioxidant property, enhanced carcinogen detoxification, inhibition of cell invasion, and by inhibiting angiogenesis. Here, in the present study we aimed to evaluate and synergize the cytotoxic activity of sulfonamide and selenium (SM+SE) as effective therapy in the treatment of DENA-induced HCC. Hepatocarcinogeneis was induced by a single intraperitoneal injection of diethylnitrosamine (DENA) (200 mg/kg) in phosphate buffer. 30 Male Wistar rats used in this study were divided randomly into five equal groups (
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