HLA in Georgians (Caucasus) and their relationship with Eastern Mediterraneans

Author: Rey Diego   Areces Cristina   Alonso-Rubio Javier   Enríquez-de-Salamanca Mercedes   Abd-El-Fatah-Khalil Sedeka   Bendikuze Nina   Fernández-Honrado Mercedes   Barbolla Luz   Martín-Villa José   Arnaiz-Villena Antonio  

Publisher: Springer Publishing Company

ISSN: 0301-4851

Source: Molecular Biology Reports, Vol.40, Iss.10, 2013-10, pp. : 5523-5530

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Abstract

HLA-A, -B, -DQB1, and –DRB1 typing has been performed in a sample of Georgian population (South Caucasus). Allele frequencies, neighbour joining and correspondence relatedness analyses and extended HLA haplotypes have been obtained with comparison with other Middle East and Mediterranean populations. Our Georgian sample tends to be genetically related in these analyses with Eastern Mediterraneans and Middle East people. This is important for future regional transplant programs, and Georgian HLA and disease epidemiology and pharmacogenomics.

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