Author： Oliveira Edson Sandri Silvana Knebel Franciele Contesini Caroline Campa Ana Filippin-Monteiro Fabíola
Publisher： Springer Publishing Company
ISSN： 0360-3997
Source： Inflammation, Vol.36, Iss.5, 2013-10, pp. : 1107-1110
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Abstract
Hypoxia has been implicated as a possible cause of adipose tissue inflammation. Furthermore, the acute phase protein serum amyloid A (SAA) has been associated with the modulation of the adipogenic process, and it is well-known that obese individuals have increased levels of SAA. The effect of hypoxia in the expression and production of SAA was examined in murine 3T3-L1 adipocytes. Hypoxia leads to a substantial increase in SAA3 mRNA and protein level, apparently in a time-dependent manner (threefold in 48 h), in fully differentiated 3T3-L1, followed by reestablishment of gene expression to basal levels after 24 h of reoxygenation. Hypoxia-induced SAA may be one of the key molecules to the development of the inflammatory response in adipose tissue.
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