Synthesis and cardiovascular activity of some azaheterocycles with carbamate groups

Author: Velikorodov A.   Tyurenkov I.   Timchenko M.   Perfilova V.  

Publisher: Springer Publishing Company

ISSN: 0091-150X

Source: Pharmaceutical Chemistry Journal, Vol.40, Iss.4, 2006-04, pp. : 182-185

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Abstract

A series of 3-aryl(methyl)-5-(N-phenylaminocarboxymethyl)-2-isoxazoles and sodium salts of 5(6)-alkoxycarbonylamino derivatives of 2-aryl-1-hydroxybenzimidazole-3-oxides were synthesized using 1,3-dipolar cycloaddition reactions between carbonitrile N-oxides and functional derivatives of N-arylcarbamates. The obtained compounds were tested for cardiovascular activity. The hypertensive effect of hetarylcarbamates and the antiischemic properties of benzimidazole-3-oxide derivatives depend on the nature (electron structure) of substituents and on their positions in the benzene ring.