Synthesis, antitumor, and anti-monoamine oxidase properties of 2,4,4-trisubstituted triazolobenzo[h]quinazolines

Author: Markosyan A.   Dilanyan S.   Arsenyan F.   Sukasyan R.   Sarkisyan I.   Garibdzhanyan B.  

Publisher: Springer Publishing Company

ISSN: 0091-150X

Source: Pharmaceutical Chemistry Journal, Vol.44, Iss.3, 2010-07, pp. : 111-114

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Abstract

The interaction of 1-amino-3-methyl-3-ethyl-3,4-dihydronaphthaline-2-carbonitrile (I) with propanoic acid chloranhyride was used to synthesize the corresponding amidonitrile II, which was then cyclized to form 2,5-diethyl-5-methyl-4-oxo-5,6-dihydrobenzo[h]quinazolin-4(3H)-one (III). Interaction of aminonitrile I with triethylorthoformate and carboxylic acid hydrazides yielded 2-substituted 4-methyl-4-ethyl-4,5-dihydrobenzo[h][1, 2, 4] triazolo[1,5-c]quinazolines (IV-XVIII). The antitumor and anti-monoamine oxidase properties of the compounds obtained were studied.

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