Author： Tskhovrebova Larissa Houmeida Ahmed Trinick John
Publisher： Springer Publishing Company
ISSN： 0142-4319
Source： Journal of Muscle Research and Cell Motility, Vol.26, Iss.6-8, 2005-12, pp. : 285-289
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Abstract
Recent progress in understanding the role of titin/connectin in muscle elasticity has been heavily based on results from single molecule mechanical experiments. The shape of force–extension curves from such data is similar to curves from muscle fibres and it has been tempting to assume that muscle elasticity can be extrapolated directly from the single molecule data. In this paper we discuss some of the factors that act on titin in the sarcomere that are likely to preclude such a direct extrapolation.
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