Coinfection: Helicobacter pylori/Human Immunodeficiency Virus

Author： Olmos Martin Araya Valentina Pskorz Eduardo Quesada Eduardo Coronado Concetti Hugo Perez Hector Cahn Pedro

ISSN： 0163-2116

Source： Digestive Diseases and Sciences, Vol.49, Iss.11-12, 2004-11, pp. : 1836-1839

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Abstract

To compare H. pylori infection prevalence and gastric mucosa damage in HIV-infected and non-HIV-infected patients, gastric biopsies were systematically taken in 209 individuals who underwent upper Gl endoscopy (102 HIV-infected and 107 non-HIV-infected). H. pylori was found in 42 (41.1%) HIV-infected patients and in 53 (49.5%) non-HIV patients (P=0.22, χ² = 1.47, NS). In HIV-positive patients infected with H. pylori the mean CD4 count was higher than in HIV-positive patients without H. pylori (364 and 228 cells/mm³, respectively; P = 0.0001). H. pylori gastritis was more severe in the HIV-positive group (χ² = 15.02, P = 0.0001). The frequency of H. pylori in gastric mucosa in HIV-infected and non-HIV patients was similar. HIV-infected patients with H. pylori had a higher mean CD4 count than HIV-infected individuals without H. pylori. Gastric lesions associated with H. pylori were more severe in the HIV-positive population.