

Author: Dore Maria Pedroni Antonietta Pes Gianni Maragkoudakis Emanouil Tadeu Vincenza Pirina Pietro Realdi Giuseppe Delitala Giuseppe Malaty Hoda
Publisher: Springer Publishing Company
ISSN: 0163-2116
Source: Digestive Diseases and Sciences, Vol.52, Iss.2, 2007-02, pp. : 463-468
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The effect of proton pump inhibitor (PPI) therapy on extraesophageal or atypical manifestations of gastroesophageal reflux disease (GERD) remains unclear. This study aimed to evaluate the prevalence of atypical manifestations in patients with acid reflux disease and the effect of PPI treatment. Patients with symptoms and signs suggestive of reflux were enrolled. Erosive esophagitis was stratified using the Los Angeles classification. Demographic data and symptoms were assessed using a questionnaire and included typical symptoms (heartburn, regurgitation, dysphagia, odynophagia), and atypical symptoms (e.g., chest pain, sialorrhea, hoarseness, globus sensation, chronic coughing, episodic bronchospasm, hiccup, eructations, laryngitis, and pharyngitis). Symptoms were reassessed after a 3-month course of b.i.d. PPI therapy. A total of 266 patients with a first diagnosis of GERD (erosive, 166; nonerosive, 100) were entered in the study. Presentation with atypical symptoms was approximately equal in those with erosive GERD and with nonerosive GERD, 72% vs 79% (
Related content




Gastroesophageal Reflux and Atypical Symptoms: The Role of Impedance-pH Monitoring
Digestion, Vol. 76, Iss. 3-4, 2007-12 ,pp. :




Endoscopic Therapy for Gastroesophageal Reflux Disease: A Systematic Review
Digestion, Vol. 74, Iss. 1, 2006-11 ,pp. :


By Yoshida Norimasa Kamada Kazuhiro Tomatsuri Naoya Suzuki Takahiro Takagi Tomohisa Ichikawa Hiroshi Yoshikawa Toshikazu
Digestive Diseases and Sciences, Vol. 55, Iss. 12, 2010-12 ,pp. :