Author: Shanab Ahmed Scully Paul Crosbie Orla Buckley Martin O’Mahony Liam Shanahan Fergus Gazareen Sanaa Murphy Eileen Quigley Eamonn
Publisher: Springer Publishing Company
ISSN: 0163-2116
Source: Digestive Diseases and Sciences, Vol.56, Iss.5, 2011-05, pp. : 1524-1534
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Abstract
Experimental and clinical studies suggest an association between small intestinal bacterial overgrowth (SIBO) and nonalcoholic steatohepatitis (NASH). Liver injury and fibrosis could be related to exposure to bacterial products of intestinal origin and, most notably, endotoxin, including lipopolysaccharide (LPS).To compare the prevalence of SIBO and its relationships to LPS receptor levels and systemic cytokines in NASH patients and healthy control subjects.Eighteen NASH patients (eight males) and 16 age-matched and gender-matched healthy volunteers were studied. SIBO was assessed by the lactulose breath hydrogen test (LHBT), plasma lipopolysaccharide binding protein (LBP) levels by ELISA, and expression (as a percentage) of TLR-2 and 4 on CD14-positive cells by flow cytometry. Pro-inflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-α) were measured in plasma.SIBO was more common in NASH patients than control subjects (77.78% vs. 31.25%;
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