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Primary skull-based yolk-sac tumour: case report and review of central nervous system germ cell tumours

Author: Verma Raman   Malone Shawn   Canil Christina   Jansen Gerard   Lesiuk Howard  

Publisher: Springer Publishing Company

ISSN: 0167-594X

Source: Journal of Neuro-Oncology, Vol.101, Iss.1, 2011-01, pp. : 129-134

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Abstract

Primary intra-cranial germ-cell tumours (GCT) are rare and it is important to differentiate them histologically as their prognosis and treatment is quite different. Moreover, highly malignant non-germinomatous GCT (NG GCT) comprise a small portion of these tumours with limited data available on appropriate treatment approaches. We present the case of a 22-year-old male with a unique primary skull-based yolk-sac subtype NG GCT with a literature review of current treatment options. To our knowledge, there have not been any previously published reports of a primary yolk-sac tumour arising from the petrous apex.

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