Mechanisms of angiotensin II-induced platelet-derived growth factor gene expression

Author: Khachigian L.M.   Takuwa Y.   Collins T.  

Publisher: Springer Publishing Company

ISSN: 0300-8177

Source: Molecular and Cellular Biochemistry, Vol.212, Iss.1-2, 2000-09, pp. : 183-186

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Angiotensin II induces the expression of platelet-derived growth factor A-chain and B-chain in cultured vascular smooth muscle cells at the level of transcription. The renin-angiotensin system has also been implicated in the increased expression of platelet-derived growth factor in the mechanically-injured artery wall. This review is concerned with recent developments in our understanding of the signaling and transcriptional mechanisms mediating the inducible expression of one vasoconstrictor by another.

Related content