Author: Khachigian L.M. Takuwa Y. Collins T.
Publisher: Springer Publishing Company
ISSN: 0300-8177
Source: Molecular and Cellular Biochemistry, Vol.212, Iss.1-2, 2000-09, pp. : 183-186
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Abstract
Angiotensin II induces the expression of platelet-derived growth factor A-chain and B-chain in cultured vascular smooth muscle cells at the level of transcription. The renin-angiotensin system has also been implicated in the increased expression of platelet-derived growth factor in the mechanically-injured artery wall. This review is concerned with recent developments in our understanding of the signaling and transcriptional mechanisms mediating the inducible expression of one vasoconstrictor by another.
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