Author: El-Bacha Tatiana Menezes Maíra M.T. Azevedo e Silva Melissa C. Sola-Penna Mauro Da Poian Andrea T.
Publisher: Springer Publishing Company
ISSN: 0300-8177
Source: Molecular and Cellular Biochemistry, Vol.266, Iss.1-2, 2004-11, pp. : 191-198
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Abstract
Although it is well established that cellular transformation with tumor virus leads to changes on glucose metabolism, the effects of cell infection by non-transforming virus are far to be completely elucidated. In this study, we report the first evidence that cultured Vero cells infected with the alphavirus Mayaro show several alterations on glucose metabolism. Infected cells presented a two fold increase on glucose consumption, accompanied by an increment in lactate production. This increase in glycolytic flux was also demonstrated by a significant increase on the activity of 6-phosphofructo 1-kinase, one of the regulatory enzymes of glycolysis. Analysis of the kinetic parameters revealed that the regulation of 6-phosphofructo 1-kinase is altered in infected cells, presenting an increase in
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