Author: Costa Madalena Águas Artur
Publisher: Springer Publishing Company
ISSN: 0360-3997
Source: Inflammation, Vol.28, Iss.6, 2004-12, pp. : 355-357
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Abstract
Growing melanomas invade the subcutaneous tissues. We have compared the size of tumors implanted in the subcutaneous cavities of C57BL/6 mice where inflammatory reactions were induced before the injection of 5×105 melanoma cells (B16F10 cell line). Granulocytic inflammation of the subcutaneous cavities resulted in a significant decrease in the growth of the implanted melanomas, whereas monocytic inflammation had no effect on tumor growth. We conclude that granulocytes, but not monocytes/macrophages, have anti-tumor action on melanoma that invade the subcutaneous tissues.
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