Inflammatory Granulocytes Decrease Subcutaneous Growth of Melanoma in Mice

Author: Costa Madalena   Águas Artur  

Publisher: Springer Publishing Company

ISSN: 0360-3997

Source: Inflammation, Vol.28, Iss.6, 2004-12, pp. : 355-357

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Growing melanomas invade the subcutaneous tissues. We have compared the size of tumors implanted in the subcutaneous cavities of C57BL/6 mice where inflammatory reactions were induced before the injection of 5×105 melanoma cells (B16F10 cell line). Granulocytic inflammation of the subcutaneous cavities resulted in a significant decrease in the growth of the implanted melanomas, whereas monocytic inflammation had no effect on tumor growth. We conclude that granulocytes, but not monocytes/macrophages, have anti-tumor action on melanoma that invade the subcutaneous tissues.