Author: Ramsay Euan Alnajim Jehan Anantha Malathi Taggar Aman Thomas Anitha Edwards Katarina Karlsson Göran Webb Murray Bally Marcel
Publisher: Springer Publishing Company
ISSN: 0724-8741
Source: Pharmaceutical Research, Vol.23, Iss.12, 2006-12, pp. : 2799-2808
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Abstract
To determine whether entrapped transition metals could mediate the active encapsulation of the anticancer drug irinotecan into preformed liposomes. Further, to establish that metal complexation could stabilize liposomal irinotecan in the therapeutically active lactone conformation.Irinotecan was added to preformed 1,2-distearoyl-