Validation of the English version of the Asthma Quality of Life Questionnaire in a multi-ethnic Asian population

Author： Tan Wan C. Tan Justina W.L. Wee Eric W.L. Niti Matthew Ng Tze P.

ISSN： 0962-9343

Source： Quality of Life Research, Vol.13, Iss.2, 2004-03, pp. : 551-556

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Abstract

The purpose of study was to assess the validity, reliability and acceptability of the English version of the Asthma Quality of Life Questionnaire in a multi-ethnic Asian population. The English version of the Standardized Asthma Quality of Life Questionnaire (AQLQ-S) and the Asthma Control Questionnaire (ACQ) were self-completed by 119 English-speaking Chinese, Malay and Indian asthmatic subjects, aged 17–78. Spirometric measurements, peak expiratory flow rate, current clinical symptoms and treatment requirements were documented. Reliability and responsiveness were analyzed in a subgroup of 57 patients who were reassessed 6 weeks later. The Cronbach α reliability coefficient for internal consistency of the AQLQ-S was 0.97 (0.96–0.98) for the overall score. The intraclass correlation coefficient (ICC) overall score was 0.97 (95% CI: 0.94–0.99) while the responsiveness index was 1.29 with strong longitudinal validity for clinical and spirometric measures of asthma severity and asthma control score (p < 0.001). The results of this study showed that the English version of the AQLQ-S is a sensitive and valid instrument for measuring health-related quality of life in asthmatic subjects from a multi-ethnic Asian population.