Once Daily Dosing Improves Adherence to Antiretroviral Therapy

Author： Raboud Janet Li Maggie Walmsley Sharon Cooper Curtis Blitz Sandra Bayoumi Ahmed Rourke Sean Rueda Sergio Rachlis Anita Mittmann Nicole Smieja Marek Collins Evan Loutfy Mona

Publisher： Springer Publishing Company

ISSN： 1090-7165

Source： AIDS and Behavior, Vol.15, Iss.7, 2011-10, pp. : 1397-1409

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Abstract

We studied the association of once-daily dosing with self-reported adherence among participants of the Ontario Cohort Study who were currently taking ART and who had completed a 90-min interviewer-administered questionnaire. Suboptimal adherence was defined as missing ≥1 dose of ART in the 4 days prior to the interview. Participants (n = 779) were 85% male, 69% men having sex with men, 67% white, median age 48 years (IQR 42–54), median years of ART 9 (IQR 5–13) and median CD4 count 463 cells/mm³ (IQR 320–638). Fifteen percent of participants reported suboptimal adherence in the 4 days prior to the interview. In a multivariable logistic regression model, participants on once daily regimens were half as likely to miss a dose during the 4 days prior to the interview. Other independent correlates of suboptimal adherence were younger age, lower positive social interaction and increased frequency of consuming > 6 alcoholic drinks on one occasion.