Determination of Vitamin B12 in Infant Formula and Adult Nutritionals by HPLC: First Action 2011.10

Author： Schimpf Karen   Spiegel Renee   Thompson Linda   Dowell Dawn  

Publisher： AOAC International

ISSN： 1944-7922

Source： Journal of AOAC International, Vol.95, Iss.2, 2012-04, pp. : 313-318

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Abstract

During the “Standards Development and International Harmonization: AOAC INTERNATIONAL Mid-Year Meeting” held on June 29, 2011, an Expert Review Panel (ERP) reviewed the method “Determination of Vitamin B12 in Infant Formula and Adult Nutritionals by HPLC.” Under the new pathway to Official MethodsSM, the ERP adopted the method as Official First Action. The method is applicable to the determination of vitamin B12 in infant formula and adult nutritionals. Data showed an average overall intermediate precision of 6.64% RSD, an estimated quantitation limit of 0.8 μg/kg, and a detection limit of 0.2 μg/kg in prepared samples. The standard range of the method is 2 to 200 μg/L, which corresponds to an analytical range of 0.8 to 500 μg/kg.

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