Author: Edwards-Lee Terri Wen Johnny Chung Julia Vasinrapee Panukorn Mishkin Frederick
Publisher: Routledge Ltd
ISSN: 1355-4794
Source: Neurocase, Vol.15, Iss.1, 2008-12, pp. : 53-59
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Clinical characteristics of autosomal dominant Alzheimer's disease often differ clinically from sporadic disease with the onset of seizures, spasticity and myoclonus early in the disease course. Similarly imaging characteristics may also differ. We report the findings of relative hyperperfusion by Tc-99m HMPAO SPECT in the medial orbitofrontal cortex and anterior temporal lobe in four affected family members carrying a presenilin 1 mutation. SPECT of the four individuals was compared to an age-matched normal database. We speculate that the findings of relative medial orbitofrontal and anterior temporal lobe hyperperfusion may be a marker of early onset Alzheimer's disease in this family.
Related content
Alzheimer's disease due to an intronic presenilin-1 ( PSEN1 intron 4) mutation
By Cipolotti L.
Brain, Vol. 123, Iss. 5, 2000-05 ,pp. :
By Pak Kirk Chan Sic L. Mattson Mark P.
NeuroMolecular Medicine, Vol. 3, Iss. 1, 2003-02 ,pp. :
By Lee J. Chan S.L. Mattson M.P.
NeuroMolecular Medicine, Vol. 2, Iss. 1, 2002-08 ,pp. :