Electrochemical Oxidation of Pentoxifylline and its Analysis in Pure and Pharmaceutical Formulations at a Glassy Carbon Electrode

Author： Hegde Rajesh Nandibewoor Sharanappa

Publisher： Taylor & Francis Ltd

ISSN： 0003-2719

Source： Analytical Letters, Vol.41, Iss.6, 2008-04, pp. : 977-991

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Abstract

The oxidative behavior of pentoxifylline was studied at a glassy carbon electrode in phosphate buffer solutions using cyclic and differential-pulse voltammetry. The oxidation process was shown to be irreversible over the pH range (3.0-9.0) and was diffusion controlled. The possible mechanism of the oxidation of pentoxifylline was investigated by means of cyclic voltammetry and UV-Vis spectroscopy. An analytical method was developed for the determination of pentoxifylline in phosphate buffer solution at pH 3.0 as a supporting electrolyte. The anodic peak current varied linearly with pentoxifylline concentration in the range 2.0 × 10-8 M to 6.0 × 10-7 M of pentoxifylline with a limit of detection (LOD) of 4.42 × 10-10 M. The proposed method was applied to the determination of pentoxifylline in pure and pharmaceutical formulations.