Synthesis of 3-Trifluoromethyl-Substituted Benzo[f]chromene Derivatives in a One-Pot Reaction

Author: Fan Hua-Fang   Wang Xiao-Wei   Zhao Jing-Wei   Li Xin-Jin   Gao Jin-Ming   Zhu Shi-Zheng  

Publisher: Taylor & Francis Ltd

ISSN: 0039-7911

Source: Synthetic Communications, Vol.43, Iss.21, 2013-11, pp. : 2883-2891

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

In the presence of 1,8-diazabicycolo[5.4.0]undec-7-ene (DBU) and concentrated H2SO4, 2-naphthol reacted smoothly with α,β-unsaturated trifluoromethyl ketones in CH2Cl2 at room temperature, affording the 3-trifluoromethyl-substituted benzo[f]chromene derivatives in good to excellent yields in a one-pot reaction.[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource: Full experimental and spectral details].

Related content