Bio-Relevant Derivatives of Calixarene Phosphonic Acids

Author： Cherenok S.   Vovk A.   Muravyova I.   Marcinowicz A.   Poznanski J.   Muzychka O.   Kukhar V.   Zielenkiewicz W.   Kalchenko V.  

Publisher： Taylor & Francis Ltd

ISSN： 1042-6507

Source： Phosphorus, Sulfur, and Silicon and the Related Elements, Vol.183, Iss.2-3, 2008-02, pp. : 638-639

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Abstract

The calix[4]arenes functionalized at the macrocyclic upper rim with α-hydroxyphosphonic, α-aminophosphonic or methylnebisphosphonic acid groups were synthesized. The complexes formed between the bio-relevent calix[4]arene derivatives and amino acids or dipeptides as well as inhibition effects of calix[4]arene phosphonic acids on alkyline phosphatases acitiy were studied.

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